Joe Manganiello particulars ‘brutal negative effects’ of secret well being battle: ‘I suffered in silence’

Joe Manganiello particulars ‘brutal negative effects’ of secret well being battle: ‘I suffered in silence’


Joe Manganiello revealed extra about his alarming health battle that he saved secret for nearly a decade.

The “True Blood” alum, in an Instagram video Wednesday, stated he “suffered in silence battling a lethal thriller sickness” he solely informed a small circle of family members about. He recalled seeing “the very best medical doctors on this planet,” whom he stated couldn’t determine what began his situation.

“All their makes an attempt to deal with it with high-powered organic medicine solely exacerbated my signs after which unlocked a bunch of brutal negative effects that winded up plaguing me for years,” Manganiello stated.

“After which in makes an attempt to purchase myself time,” he continued, “I underwent very critical operations and procedures that mutilated components of my physique and left me so weak at instances that I couldn’t arise or stroll.”

Joe Manganiello revealed extra about his secret sickness he battled for nearly a decade in an Instagram video Wednesday (a screenshot of which is seen above). Instagram/Joe Manganiello
The “True Blood” alum (seen right here within the social media publish) stated medical doctors couldn’t determine what began his sickness however prescribed him “high-powered organic medicine” that gave him “brutal negative effects.” Instagram/Joe Manganiello

The “Magic Mike” alum, 49, additionally shared that he spent months “closely medicated whereas coping with excruciating bouts of power ache.” He famous that his upcoming memoir, “Bloodlines,” out Oct. 13, paperwork his 10-year seek for solutions in addition to a deep dive into his household’s historical past.

“Perhaps what occurred to me wasn’t random,” he says. “And that as a way to heal, my thoughts, my physique, my spirit all needed to align and I wanted to turn out to be open to some actually radical and unorthodox methods and concepts that lie past the boundaries of western drugs.”

Manganiello shared a supportive message for many who could be going by an identical scenario.

“Should you’re on the market and also you’re struggling, there’s hope,” he stated.

Manganiello — pictured right here in March 2025 — stated he handled the negative effects for years and likewise underwent operations that “mutilated” components of his physique. Getty Pictures
His upcoming memoir, “Bloodlines” (the duvet of which is seen right here), paperwork his sickness and the choice therapies he sought. Simon & Schuster

In a synopsis for “Bloodlines,” Manganiello shares that he handled “a cascade of autoimmune-related diseases” that attacked his thyroid, digestive system, pores and skin, lungs and eyes.

Over the course of seven years, he revealed that he handled “power ache, a life-saving organ amputation, existential disaster and a protracted battle for survival that left medical doctors with few solutions and no clear clarification.”

Manganiello ended up turning to different drugs like “shamans, pagan rituals, historic myths, long-lost household information and the rebirth of his personal spirituality” to assist deal with his sickness.

The previous “Deal or No Deal Island” host additionally did intensive analysis into his circle of relatives family tree and found ancestors who survived the Armenian genocide and others who lived with power sickness.

Manganiello (pictured right here in a social media publish) has not but revealed the years he suffered from his sickness. Instagram/joemanganiello
The actor introduced his engagement to actress Caitlin O’Connor final October. They’re pictured right here in April 2025. WireImage

Manganiello has not revealed the years his well being battle occurred.

He was beforehand married to actress Sofía Vergara, 53, from 2015 to 2024. The “Trendy Household” alum stated in January 2024 that the 2 break up as a result of she didn’t want to have kids with him and be “an previous mother.”

“I really feel it’s not honest to the infant,” she informed El País.

Vergara is already a mother to her son, 34-year-old Manolo, whom she shares with ex-husband Joe Gonzalez.

Manganiello is now engaged to actress Caitlin O’Connor, 36, which the couple introduced final October.